A study on clavulanic acid production by Streptomyces clavuligerus in batch, fed-batch and continuous processes
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چکیده
منابع مشابه
A STUDY ON CLAVULANIC ACID PRODUCTION BY Streptomyces clavuligerus IN BATCH, FED-BATCH AND CONTINUOUS PROCESSES
Clavulanic acid (CA) is a potent inhibitor of β-lactamases, enzymes that are responsible for the hydrolysis of β-lactam antibiotics. It is a secondary metabolite produced by the filamentous aerobic bacterium Streptomyces clavuligerus in submerged cultivations. In the present work clavulanic acid production in batch, fed-batch and continuous bioreactors was studied with the objective of increasi...
متن کاملPRODUCTION OF CLAVULANIC ACID AND CEPHAMYCIN C BY Streptomyces clavuligerus UNDER DIFFERENT FED-BATCH CONDITIONS
The effect of carbon source and feeding conditions on the production of clavulanic acid (CA) and cephamycin C (CephC) by Streptomyces clavuligerus was investigated. In fed-batch experiments performed with glycerol feeding, production of CA exceeded that of CephC, and reached 1022 mg.L. Highest CephC production (566.5 mg.L) was obtained in fed-batch cultivation with glycerol feeding. In fed-batc...
متن کاملProduction of Clavulanic Acid by Streptomyces clavuligerus in Batch Cultures with Using Wheat Bran as the Source of Carbon
Nowadays Microbial biotechnology is considered as one of the most important and profitable branches of industry. In this approach, by using the generator microorganisms, We are able to produce biotechnological products, with higher efficiency. Clavulanic acid is being used in combination with commonly used beta-lactam antibiotics in order to fight against bacterial infections that are resistant...
متن کاملEnhancement of clavulanic acid production by mutant Streptomyces clavuligerus
β-lactam antibiotics are among the most popular classes of antibacterial agents, whose mechanism of action consists on the inhibition of bacterial cell wall synthesis.1 The production of β-lactamase is the most important mechanism for bacterial resistance to β-lactam antibiotics.2 Secondary metabolites produced by bacteria exhibit potent biological activities and have been developed extensively...
متن کاملproduction of clavulanic acid by streptomyces clavuligerus in batch cultures with using wheat bran as the source of carbon
nowadays microbial biotechnology is considered as one of the most important and profitable branches of industry. in this approach, by using the generator microorganisms, we are able to produce biotechnological products, with higher efficiency. clavulanic acid is being used in combination with commonly used beta-lactam antibiotics in order to fight against bacterial infections that are resistant...
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ژورنال
عنوان ژورنال: Brazilian Journal of Chemical Engineering
سال: 2005
ISSN: 0104-6632
DOI: 10.1590/s0104-66322005000400008